[Feature] Young blood

Young animals' blood holds rejuvenating powers. Amy Wagers wants to know why. Author: Stephen S. Hall

[Perspective] Morality beyond the lab

Much of moral life involves attending to our own good deeds and to the bad deeds of others [Also see Report by Hofmann et al.] Author: Jesse Graham

[Perspective] Microbes ride the current

Biogeographical diversity in bacterial populations can arise without need for natural selection [Also see Report by Hellweger et al.] Authors: Stephen Giovannoni, Diana Nemergut

[Perspective] Diamond dynamics under control

Ultrafast spectroscopy is used to control and manipulate quantum states in diamond [Also see Report by Bassett et al.] Author: Lilian Childress

[Perspective] Innate lymphoid cells sweeten the pot

Immune cells prompt gut epithelial cells to produce carbohydrate nutrients for resident bacteria [Also see Research Article by Goto et al.] Author: Lora V. Hooper

[Letter] Retraction

Authors: Tatsuaki Okada, Kei Shirai, Yukio Yamamoto, Takehiko Arai, Kazunori Ogawa, Kozue Hosono, Manabu Kato

[Editorial] Culture of responsibility

The current crisis with the Ebola virus vividly illustrates the priority that must be given to infectious diseases because of their potentially devastating consequences to individuals and to society. Few would argue against the need for more research on Ebola and the expedited development of a cure; however, recent incidents in biocontainment laboratories and the proliferation of such facilities globally raise concerns about safety and have split the scientific community. Scientists who defend research on dangerous pathogens as vital to protecting populations are opposed by those who fear the potential devastation caused by the intentional or unintentional release of pathogens from the lab. Achieving a “culture of safety,” so often alluded to after recent lapses in biosafety procedures, demands adopting a “culture of responsibility” as well. Authors: Ruth L. Berkelman, James W. Le Duc

[In Depth] Cellulosic ethanol at last?

Large volumes of fuel from crop wastes will soon start flowing in the U.S.—unless policymakers balk. Author: Robert F. Service

[Feature] The catalyst

Marc Lipsitch wants to turn the bitter debate over risky virus research into a search for solutions. Author: Jocelyn Kaiser

[Perspective] Greenland deglaciation puzzles

Nitrogen isotope data help to resolve puzzling observations during the last deglaciation [Also see Report by Buizert et al.] Author: Louise Claire Sime

[Perspective] Clogging information flow in ALS

Dipeptide repeat proteins produced in certain neurodegenerative diseases exert toxicity by blocking RNA biogenesis [Also see Research Article by Kwon et al. and Report by Mizielinska et al.] Authors: Joseph Paul West, Aaron D. Gitler

[Perspective] Particle physics in a superconductor

A superconducting condensate can display analogous behavior to the Higgs field [Also see Report by Matsunaga et al.] Authors: Alexej Pashkin, Alfred Leitenstorfer

[Perspective] A wake-up call with coffee

Recording and archiving crop phenotype diversity needs to catch up with genomic data [Also see Report by Denoeud et al.] Author: Dani Zamir

[Technical Comment] Comment on “Local impermeant anions establish the neuronal chloride concentration”

Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, “local impermeant anions establish the neuronal chloride concentration” and thereby determine “the magnitude and direction of GABAAR currents at individual synapses.” If this were possible, perpetual ion-motion machines could be constructed. The authors’ conclusions conflict with basic thermodynamic principles. Authors: Juha Voipio, Walter F. Boron, Stephen W. Jones, Ulrich Hopfer, John A. Payne, Kai Kaila

[Technical Comment] Comment on “Local impermeant anions establish the neuronal chloride concentration”

Glykys et al. (Reports, 7 February 2014, p. 670) proposed that cytoplasmic impermeant anions and polyanionic extracellular matrix glycoproteins establish the local neuronal intracellular chloride concentration, [Cl–]i, and thereby the polarity of γ-aminobutyric acid type A (GABAA) receptor signaling. The experimental procedures and results in this study are insufficient to support these conclusions. Contradictory results previously published by these authors and other laboratories are not referred to. Authors: Heiko J. Luhmann, Sergei Kirischuk, Werner Kilb

This Week in Science

Tuning the twisting in helical nanowires | A metal alloy that is stronger when cold | Bringing up baby | Dipeptide repeat peptides on the attack | Connecting DNA damage to fibrosis | Coffee, tea, and chocolate converge | Old and older, cold and colder | Genome editing corrects a muscle disease | Caught in the act of making protein | Surprise found by γ-ray metal detector | The earthquake that rocked northern Chile | Optically manipulating superconductors | Cofactors linked to nutrient limitation | Watching nucleation pathways in calcite | Bringing in the agent of your own destruction | Liquid crystals on a deformable substrate | Protein markers of cyanobacterial stress

Editors' Choice

A long noncoding RNA helps cells divide | A drug's two-part way to block dopamine | Anthropogenic de-icing on a grand scale | Tolerating aluminum | Layers of ways to control drug release | Quantum imaging of Schrödinger's cat | An edgy way to transform carbon dioxide | When genetic diversity hurts the kids

[Research Article] Topology and dynamics of active nematic vesicles

Dynamical shape-changing materials result from merging active liquid crystals with soft deformable vesicles. Authors: Felix C. Keber, Etienne Loiseau, Tim Sanchez, Stephen J. DeCamp, Luca Giomi, Mark J. Bowick, M. Cristina Marchetti, Zvonimir Dogic, Andreas R. Bausch