[Report] The ancient heritage of water ice in the solar system

A model tracing the path of deuterium in the solar system shows that its abundance hails from the parent interstellar medium. Authors: L. Ilsedore Cleeves, Edwin A. Bergin, Conel M. O’D. Alexander, Fujun Du, Dawn Graninger, Karin I. Öberg, Tim J. Harries

[Report] Early Levallois technology and the Lower to Middle Paleolithic transition in the Southern Caucasus

An assemblage of obsidian artifacts suggests independent origins of stone knapping in different hominin populations. Authors: D. S. Adler, K. N. Wilkinson, S. Blockley, D. F. Mark, R. Pinhasi, B. A. Schmidt-Magee, S. Nahapetyan, C. Mallol, F. Berna, P. J. Glauberman, Y. Raczynski-Henk, N. Wales, E. Frahm, O. Jöris, A. MacLeod, V. C. Smith, V. L. Cullen, B. Gasparian

[Report] Semiaquatic adaptations in a giant predatory dinosaur

New fossils of the sail-finned predatory dinosaur Spinosaurus reveal that it lived in and near water. Authors: Nizar Ibrahim, Paul C. Sereno, Cristiano Dal Sasso, Simone Maganuco, Matteo Fabbri, David M. Martill, Samir Zouhri, Nathan Myhrvold, Dawid A. Iurino

[Report] Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

A mutation in a single copy of the CTLA4 gene in people is associated with immune dysfunction. [Also see Perspective by Rieux-Laucat and Casanova] Authors: Hye Sun Kuehn, Weiming Ouyang, Bernice Lo, Elissa K. Deenick, Julie E. Niemela, Danielle T. Avery, Jean-Nicolas Schickel, Dat Q. Tran, Jennifer Stoddard, Yu Zhang, David M. Frucht, Bogdan Dumitriu, Phillip Scheinberg, Les R. Folio, Cathleen A. Frein, Susan Price, Christopher Koh, Theo Heller, Christine M. Seroogy, Anna Huttenlocher, V. Koneti Rao, Helen C. Su, David Kleiner, Luigi D. Notarangelo, Yajesh Rampertaap, Kenneth N. Olivier, Joshua McElwee, Jason Hughes, Stefania Pittaluga, Joao B. Oliveira, Eric Meffre, Thomas A. Fleisher, Steven M. Holland, Michael J. Lenardo, Stuart G. Tangye, Gulbu Uzel

[Association Affairs] Gordon Research Conferences

This issue of Science includes the program of the 2015 AAAS Annual Meeting. 2015 “Session I” Meetings will be held between January and May in California and Texas in the United States, and internationally in Lucca (Barga), Italy and Hong Kong, China. A PDF of the program as it appears in this issue is available here; for more information on the meeting (including registration forms and information on accommodations), please visit www.grc.org.

[New Products] New Products

A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.

[Business Office Feature] CRISPR-Cas9: Engineering a revolution in gene editing

The CRISPR-Cas9 system is revolutionizing genomic engineering and equipping scientists with the ability to precisely modify the DNA of essentially any organism. Just how powerful is this technique? The ability for precision genome engineering comes with the potential to enhance food production, medicinal discoveries, and energy solutions, to name a few. In this booklet, we invite you to explore a selection of Science articles that highlight how this technique has grown into one of the most powerful genomic engineering tools to date. CRISPR-Cas9 (PDF, 14.6 MB)CRISPR-Cas9 (PDF, low resolution version, 3.16 MB)Read the e-bookletThis booklet brought to you by the Science/AAAS Custom Publishing Office.DOI: 10.1126/science.opms.sb0002

[Editorial] Be one of the first

On 3 July 1880, “a weekly journal of scientific progress” published its first research articles under the banner Science. From that original print medium, the inaugural set of papers has been reprinted, photocopied, posted online, converted to PDF, and even etched in glass blocks to serve as special gifts. Being part of the vanguard is indeed a privilege, and opportunities to be one of the first are rare. For that reason, I proudly announce that Science Advances, a new open-access journal for all of the sciences, officially joins the Science family of journals (Science, Science Translational Medicine, and Science Signaling) and is now accepting submissions (go to www.scienceadvances.org). In February 2015, the inaugural papers will be released, heralding the start of something big in scope, reach, and influence. Author: Marcia McNutt

[Editorial] The Pope tackles sustainability

The war on environmental degradation has a powerful new ally: Pope Francis. Prompted by a Joint Workshop of the Pontifical Academy of Sciences and the Pontifical Academy of Social Sciences on sustainability that was convened in May 2014, the Vatican has articulated some of its strongest environmental statements to date, calling for all of us to take personal responsibility and redirect our relationship with nature to ensure the future habitability and sustainability of this planet (see the Perspective on p. 1457). The problems that motivate the Vatican are no different from those that concern the scientific community: depletion of nonrenewable resources, loss of ecosystem services, and risks from changing climate. But what the Vatican contributes is the rationale for taking action: because it is our moral responsibility to bequeath a habitable planet to future generations. Author: Marcia McNutt

[In Depth] All eyes on shooting stars

By tracking meteorite falls, camera and radar networks help searchers find precious fragments. Author: Eric Hand

[In Depth] Play it again, Uncle Sam

Prominent academics recommend growth in federal basic research budget that matches previous golden era Author: Jeffrey Mervis

[Feature] No miracles

Biologist Russell Gray uses evolutionary ideas to probe the origin of languages and complex thinking. Author: Virginia Morell

[Feature] Outsmarting the placebo effect

Can a genetic test to predict a person's level of placebo response help new drugs win approval? Author: Kelly Servick

[Perspective] Biomimetics and evolution

Linking biomechanical and evolutionary analysis helps to create viable biomimetic products Author: S. N. Patek

[Perspective] Superheavy carbonyls

The radioactive superheavy element seaborgium can form a carbonyl compound during its short lifetime [Also see Report by Even et al.] Author: Walter Loveland

[Perspective] Cascading into focus

Structures of a multisubunit protein-RNA complex reveal how the CRISPR system recognizes DNA targets [Also see Research Articles by Jackson et al. and Mulepati et al.] Authors: Yan Zhang, Erik J. Sontheimer