[Report] Solar nebula magnetic fields recorded in the Semarkona meteorite

Magnetic field strength in the early solar system is recorded in chondrules within a meteorite born of the asteroid Vesta. Authors: Roger R. Fu, Benjamin P. Weiss, Eduardo A. Lima, Richard J. Harrison, Xue-Ning Bai, Steven J. Desch, Denton S. Ebel, Clément Suavet, Huapei Wang, David Glenn, David Le Sage, Takeshi Kasama, Ronald L. Walsworth, Aaron T. Kuan

[Report] Increasing anthropogenic nitrogen in the North Pacific Ocean

Atmospheric deposition of nitrogen from Asian pollution has increased the nitrate concentration of the upper North Pacific Ocean. Authors: Il-Nam Kim, Kitack Lee, Nicolas Gruber, David M. Karl, John L. Bullister, Simon Yang, Tae-Wook Kim

[Report] Forgetting the presidents

People appear to update long-term lists of memories so as to retain only the most recent entries. [Also see Perspective by Rubin] Authors: H. L. Roediger, K. A. DeSoto

[Report] Cell cycle–dependent regulation of mitochondrial preprotein translocase

Cell division and mitochondrial protein import are directly linked by cyclin-dependent phosphorylation of a mitochondrial assembly factor. [Also see Perspective by Schulz and Rehling] Authors: Angelika B. Harbauer, Magdalena Opalińska, Carolin Gerbeth, Josip S. Herman, Sanjana Rao, Birgit Schönfisch, Bernard Guiard, Oliver Schmidt, Nikolaus Pfanner, Chris Meisinger

[Report] Genomic structure in Europeans dating back at least 36,200 years

An ancient human genome illuminates human demography in Eurasia and Europe. Authors: Andaine Seguin-Orlando, Thorfinn S. Korneliussen, Martin Sikora, Anna-Sapfo Malaspinas, Andrea Manica, Ida Moltke, Anders Albrechtsen, Amy Ko, Ashot Margaryan, Vyacheslav Moiseyev, Ted Goebel, Michael Westaway, David Lambert, Valeri Khartanovich, Jeffrey D. Wall, Philip R. Nigst, Robert A. Foley, Marta Mirazon Lahr, Rasmus Nielsen, Ludovic Orlando, Eske Willerslev

[Report] Nidogens are therapeutic targets for the prevention of tetanus

Preventing nidogen-tetanus toxin interaction at the neuromuscular junction can protect mice from tetanus-induced spastic paralysis. Authors: Kinga Bercsenyi, Nathalie Schmieg, J. Barney Bryson, Martin Wallace, Paola Caccin, Matthew Golding, Giuseppe Zanotti, Linda Greensmith, Roswitha Nischt, Giampietro Schiavo

[New Products] New Products

A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.

[Editorial] The drought you can't see

The Western Hemisphere is experiencing a drought of crisis proportions. In Central America, crops are failing, millions are in danger of starvation, and if the drought doesn't break soon, even vessels transiting the Panama Canal will need to lighten their loads, which will increase prices for goods transported globally. In the western United States, the drought-stricken region spans a vast area responsible for much of the nation's fruits, vegetables, and beef. As the drought's grip has tightened, water users have turned to tapping groundwater aquifers to make up the deficit for people, crops, livestock, and industry. But even when the rain does return, regreening the landscape and filling again the streams, lakes, and reservoirs, those aquifers will remain severely depleted. It is this underground drought we can't see that is enduring, worrisome, and in need of attention. Author: Marcia McNutt

[In Depth] Red wolves in the crosshairs

U.S. agency ponders future of innovative reintroduction as animal deaths and controversy mount. Author: Erik Stokstad

[Feature] On the edge

Ecologist Marten Scheffer became a leader in the science of tipping points by studying lakes. Now he's making waves in many other fields. Author: Gabriel Popkin

[Feature] NOνA's shining moment

Despite years of delay, Fermilab's massive new experiment has a chance to take the next big step in neutrino physics. Author: Adrian Cho

[Perspective] Whose conservation?

Changes in the perception and goals of nature conservation require a solid scientific basis Author: Georgina M. Mace

[Perspective] Autoimmunity by haploinsufficiency

Partial deficiency in the protein CTLA4 underlies severe autoimmune disease with incomplete penetrance [Also see Report by Kuehn et al.] Authors: Frédéric Rieux-Laucat, Jean-Laurent Casanova

[Perspective] Water's place in Au catalysis

Water plays a key role in gold-catalyzed CO oxidation [Also see Report by Saavedra et al.] Authors: Gregory M. Mullen, C. Buddie Mullins

[Perspective] Managing patterns and proportions over time

Tissue patterning is specified relative to growth through differences between cell proliferation and the differentiation rates [Also see Research Article by Kicheva et al.] Author: Olivier Pourquie

This Week in Science

A complex network makes simple pores | Crustal rebound from water drawdown | Mysterious dinosaur a swimmer? | Easier oxidation over gold with added water | Beware of T cells that don't know how to stop | Closing the loop on neuroprosthetic control | Hot electron plasma moves in from Io | Preventing vascular scarring after surgery | Differentiation rates regulate pool sizes | Carbon chains branch out on space dust | Nature or nurture for solar system ices? | A BLUEPRINT of immune cell development | Making nitrogen available for biosynthesis | The power of a pair of perovskites | Breaking down a Criegee intermediate | An early assemblage of obsidian artifacts | How plant species diversity is shaped | Animal behavior follows rewards | Views of nature, views of conservation

Editors' Choice

Timing counts for whisker development | Animal behavior follows dopamine rewards | Bring out your dead — hungry receptors await | An Arabian wintertime bloom on the rise | Hate and violence spread through the air | Social complexity creates brainy parrots | Teaching tolerance stops the bleeding | Constructing a maze full of phosphines

[Research Article] Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Genome-wide approaches analyze human monocyte differentiation in vitro into functional macrophages. Authors: Sadia Saeed, Jessica Quintin, Hindrik H. D. Kerstens, Nagesha A. Rao, Ali Aghajanirefah, Filomena Matarese, Shih-Chin Cheng, Jacqueline Ratter, Kim Berentsen, Martijn A. van der Ent, Nilofar Sharifi, Eva M. Janssen-Megens, Menno Ter Huurne, Amit Mandoli, Tom van Schaik, Aylwin Ng, Frances Burden, Kate Downes, Mattia Frontini, Vinod Kumar, Evangelos J. Giamarellos-Bourboulis, Willem H. Ouwehand, Jos W. M. van der Meer, Leo A. B. Joosten, Cisca Wijmenga, Joost H. A. Martens, Ramnik J. Xavier, Colin Logie, Mihai G. Netea, Hendrik G. Stunnenberg

[Research Article] mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Epigenetic profiling identifies the cellular metabolic substrate of innate immune memory. Authors: Shih-Chin Cheng, Jessica Quintin, Robert A. Cramer, Kelly M. Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J. Giamarellos-Bourboulis, Joost H. A. Martens, Nagesha Appukudige Rao, Ali Aghajanirefah, Ganesh R. Manjeri, Yang Li, Daniela C. Ifrim, Rob J. W. Arts, Brian M. J. W. van der Meer, Peter M. T. Deen, Colin Logie, Luke A. O’Neill, Peter Willems, Frank L. van de Veerdonk, Jos W. M. van der Meer, Aylwin Ng, Leo A. B. Joosten, Cisca Wijmenga, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea

[Research Article] Transcriptional diversity during lineage commitment of human blood progenitors

RNA sequencing identifies how different cell fate decisions are made during blood cell differentiation. Authors: Lu Chen, Myrto Kostadima, Joost H. A. Martens, Giovanni Canu, Sara P. Garcia, Ernest Turro, Kate Downes, Iain C. Macaulay, Ewa Bielczyk-Maczynska, Sophia Coe, Samantha Farrow, Pawan Poudel, Frances Burden, Sjoert B. G. Jansen, William J. Astle, Antony Attwood, Tadbir Bariana, Bernard de Bono, Alessandra Breschi, John C. Chambers, , Fizzah A. Choudry, Laura Clarke, Paul Coupland, Martijn van der Ent, Wendy N. Erber, Joop H. Jansen, Rémi Favier, Matthew E. Fenech, Nicola Foad, Kathleen Freson, Chris van Geet, Keith Gomez, Roderic Guigo, Daniel Hampshire, Anne M. Kelly, Hindrik H. D. Kerstens, Jaspal S. Kooner, Michael Laffan, Claire Lentaigne, Charlotte Labalette, Tiphaine Martin, Stuart Meacham, Andrew Mumford, Sylvia Nürnberg, Emilio Palumbo, Bert A. van der Reijden, David Richardson, Stephen J. Sammut, Greg Slodkowicz, Asif U. Tamuri, Louella Vasquez, Katrin Voss, Stephen Watt, Sarah Westbury, Paul Flicek, Remco Loos, Nick Goldman, Paul Bertone, Randy J. Read, Sylvia Richardson, Ana Cvejic, Nicole Soranzo, Willem H. Ouwehand, Hendrik G. Stunnenberg, Mattia Frontini, Augusto Rendon