Chandler and Turelli postulate that intrinsic hybrid dysfunction underscores hybrid lethality in Nasonia. Although it is a suitable conception for examining hybrid incompatibilities, their account of the evidence is factually inaccurate and leaves out the evolutionary process for why lethality became conditional on nuclear-microbe interactions. Hybrid incompatibilities in the context of phylosymbiosis are resolved by hologenomic principles and exemplify this emerging postmodern synthesis. Authors: Robert M. Brucker, Seth R. Bordenstein

A monthly roundup of recent news and projects of Science's publisher, the American Association for the Advancement of Science.

Cost-effective conservation on private land | Signature microbes follow you from house to house | Distance score settled for Seven Sisters | Strong yet creeping megathrust faults | Rabbits softly swept to domestication | Cutting out a kinase for T cell survival | Push me, pull you, that's the way to move | An enzyme offers a new path to pain control | A cosmic dust storm that came and went | Making a superfluid lithium mixture | Catching changing boron coordination | Arctic genetics comes in from the cold | Activating a receptor to excite a neuron | Brain stimulation to improve human memory | Chromatin mutations disrupt development | T and B cells' intricate molecular dance | Oxidizing hydrogen in place of nitrite | El Niño shifted between the center and the East

Need proteasomes? Make some! | Incentives work on economists, too! | Eliminating the effects of the pesky bulk | Making mantle melt analogs more accurate | Cleaving RNA dials down inflammation | Moving from one novelty to the next | Seals infected early Americans with TB | Interior design with nanoparticles

Early Arctic humans differed from both present-day Inuit and Native Americans. [Also see Perspective by Park] Authors: Maanasa Raghavan, Michael DeGiorgio, Anders Albrechtsen, Ida Moltke, Pontus Skoglund, Thorfinn S. Korneliussen, Bjarne Grønnow, Martin Appelt, Hans Christian Gulløv, T. Max Friesen, William Fitzhugh, Helena Malmström, Simon Rasmussen, Jesper Olsen, Linea Melchior, Benjamin T. Fuller, Simon M. Fahrni, Thomas Stafford, Vaughan Grimes, M. A. Priscilla Renouf, Jerome Cybulski, Niels Lynnerup, Marta Mirazon Lahr, Kate Britton, Rick Knecht, Jette Arneborg, Mait Metspalu, Omar E. Cornejo, Anna-Sapfo Malaspinas, Yong Wang, Morten Rasmussen, Vibha Raghavan, Thomas V. O. Hansen, Elza Khusnutdinova, Tracey Pierre, Kirill Dneprovsky, Claus Andreasen, Hans Lange, M. Geoffrey Hayes, Joan Coltrain, Victor A. Spitsyn, Anders Götherström, Ludovic Orlando, Toomas Kivisild, Richard Villems, Michael H. Crawford, Finn C. Nielsen, Jørgen Dissing, Jan Heinemeier, Morten Meldgaard, Carlos Bustamante, Dennis H. O’Rourke, Mattias Jakobsson, M. Thomas P. Gilbert, Rasmus Nielsen, Eske Willerslev

X-ray structures provide insight into how an ion channel involved in activation of neurons is gated. Authors: Lei Chen, Katharina L. Dürr, Eric Gouaux

Boron atoms move out of plane with pressure as they transition from threefold to fourfold coordination in borosilicate glass. [Also see Perspective by Youngman] Authors: Trenton Edwards, Takatsugu Endo, Jeffrey H. Walton, Sabyasachi Sen

A highly accurate and precise radio measurement overrules a contrary result from the Hipparcos satellite. [Also see Perspective by Girardi] Authors: Carl Melis, Mark J. Reid, Amy J. Mioduszewski, John R. Stauffer, Geoffrey C. Bower

Variations in the brightness of warm dust indicate recent destructive collisions among protoplanets. Authors: Huan Y. A. Meng, Kate Y. L. Su, George H. Rieke, David J. Stevenson, Peter Plavchan, Wiphu Rujopakarn, Carey M. Lisse, Saran Poshyachinda, Daniel E. Reichart

An ultracold gas mixture of two lithium isotopes, one bosonic and the other fermionic, manifests superfluidity. Authors: I. Ferrier-Barbut, M. Delehaye, S. Laurent, A. T. Grier, M. Pierce, B. S. Rem, F. Chevy, C. Salomon

Megathrusts subducting rugged sea floor have high fault strength but do not unleash great earthquakes. Authors: Xiang Gao, Kelin Wang

A small portion of Brazil’s agricultural subsidies would be enough to preserve private land in the Brazilian Atlantic Forest. Authors: Cristina Banks-Leite, Renata Pardini, Leandro R. Tambosi, William D. Pearse, Adriana A. Bueno, Roberta T. Bruscagin, Thais H. Condez, Marianna Dixo, Alexandre T. Igari, Alexandre C. Martensen, Jean Paul Metzger

El Niño–Southern Oscillation warming of the sea surface was strongly skewed toward the central Pacific in the Mid-Holocene. Authors: Matthieu Carré, Julian P. Sachs, Sara Purca, Andrew J. Schauer, Pascale Braconnot, Rommel Angeles Falcón, Michèle Julien, Danièle Lavallée

Microbes colonize not only our guts, but also our homes. Authors: Simon Lax, Daniel P. Smith, Jarrad Hampton-Marcell, Sarah M. Owens, Kim M. Handley, Nicole M. Scott, Sean M. Gibbons, Peter Larsen, Benjamin D. Shogan, Sophie Weiss, Jessica L. Metcalf, Luke K. Ursell, Yoshiki Vázquez-Baeza, Will Van Treuren, Nur A. Hasan, Molly K. Gibson, Rita Colwell, Gautam Dantas, Rob Knight, Jack A. Gilbert

Bacteria thought to rely on the oxidation of nitrite for energy can, in fact, do just fine by oxidizing hydrogen instead. Authors: Hanna Koch, Alexander Galushko, Mads Albertsen, Arno Schintlmeister, Christiane Gruber-Dorninger, Sebastian Lücker, Eric Pelletier, Denis Le Paslier, Eva Spieck, Andreas Richter, Per H. Nielsen, Michael Wagner, Holger Daims

Noninvasive stimulation of the brain can improve memories for episodes by boosting the connectivity between cortical regions. Authors: Jane X. Wang, Lynn M. Rogers, Evan Z. Gross, Anthony J. Ryals, Mehmet E. Dokucu, Kelly L. Brandstatt, Molly S. Hermiller, Joel L. Voss

Live-cell imaging in mice reveals the molecular details of B cell selection in germinal centers. Authors: Ziv Shulman, Alexander D. Gitlin, Jason S. Weinstein, Begoña Lainez, Enric Esplugues, Richard A. Flavell, Joseph E. Craft, Michel C. Nussenzweig

Human fibroblast migration in a physiological extracellular matrix relies on a polarized intracellular pressure gradient. [Also see Perspective by DeSimone and Horwitz] Authors: Ryan J. Petrie, Hyun Koo, Kenneth M. Yamada

Mutations in the DNA packaging material disrupt fruit fly development and reveal epigenetic regulatory pathways. Authors: Hans-Martin Herz, Marc Morgan, Xin Gao, Jessica Jackson, Ryan Rickels, Selene K. Swanson, Laurence Florens, Michael P. Washburn, Joel C. Eissenberg, Ali Shilatifard

X-ray structures provide insight into how an ion channel involved in activation of neurons is gated. Authors: Maria V. Yelshanskaya, Minfen Li, Alexander I. Sobolevsky

The domestication of rabbits primarily shifted the frequencies of alleles represented, rather than creating new genes. [Also see Perspective by Lohmueller] Authors: Miguel Carneiro, Carl-Johan Rubin, Federica Di Palma, Frank W. Albert, Jessica Alföldi, Alvaro Martinez Barrio, Gerli Pielberg, Nima Rafati, Shumaila Sayyab, Jason Turner-Maier, Shady Younis, Sandra Afonso, Bronwen Aken, Joel M. Alves, Daniel Barrell, Gerard Bolet, Samuel Boucher, Hernán A. Burbano, Rita Campos, Jean L. Chang, Veronique Duranthon, Luca Fontanesi, Hervé Garreau, David Heiman, Jeremy Johnson, Rose G. Mage, Ze Peng, Guillaume Queney, Claire Rogel-Gaillard, Magali Ruffier, Steve Searle, Rafael Villafuerte, Anqi Xiong, Sarah Young, Karin Forsberg-Nilsson, Jeffrey M. Good, Eric S. Lander, Nuno Ferrand, Kerstin Lindblad-Toh, Leif Andersson

A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.

Reproducibility is the ugly duckling of science. It provokes distress, denial, and passionate calls for action. With $1.5 trillion spent globally each year on R&D,* the idea that 80% of it is irreproducible† can cause downright dread. It threatens the foundations and credibility of the scientific enterprise. But look past the surface, and reproducibility may well be a swan in the making. Author: Timothy Gardner

Breeding for dependence, not cooperation, may have driven initial dog domestication. Author: Virginia Morell

After years in drug development limbo, a compound that interrupts cell division has revitalized a troubled area of cancer research. Author: Ken Garber

Evidence is found for the massive stars that populated the early universe [Also see Report by Aoki et al.] Author: Volker Bromm

Sunlight drives the emission of carbon from arctic waters [Also see Report by Cory et al.] Author: Lars Tranvik

Nonlinear optics with single quanta of light and matter becomes reality [Also see Report by Shomroni et al.] Author: Gerhard Rempe

Mountain glacier loss since the 1970s has mostly been caused by human influences on climate change [Also see Report by Marzeion et al.] Author: Shawn Marshall

Including air pollution and greenhouse gas damages increases estimated U.S. growth Author: Nicholas Z. Muller