[Research Article] Topology and dynamics of active nematic vesicles

Dynamical shape-changing materials result from merging active liquid crystals with soft deformable vesicles. Authors: Felix C. Keber, Etienne Loiseau, Tim Sanchez, Stephen J. DeCamp, Luca Giomi, Mark J. Bowick, M. Cristina Marchetti, Zvonimir Dogic, Andreas R. Bausch

[Report] Early 56Ni decay gamma rays from SN2014J suggest an unusual explosion

Early exposure of material produced in a supernova suggests an asymmetric explosion from the white dwarf progenitor. Authors: Roland Diehl, Thomas Siegert, Wolfgang Hillebrandt, Sergei A. Grebenev, Jochen Greiner, Martin Krause, Markus Kromer, Keiichi Maeda, Friedrich Röpke, Stefan Taubenberger

[Report] A complex iron-calcium cofactor catalyzing phosphotransfer chemistry

An intricate triangular complex containing two iron atoms makes up the active site cofactor of a bacterial alkaline phosphatase. [Also see Perspective by Moore] Authors: Shee Chien Yong, Pietro Roversi, James Lillington, Fernanda Rodriguez, Martin Krehenbrink, Oliver B. Zeldin, Elspeth F. Garman, Susan M. Lea, Ben C. Berks

[Report] Greenland temperature response to climate forcing during the last deglaciation

Multiple proxies from ice cores show the spatial pattern of warming in Greenland over the last deglaciation. Authors: Christo Buizert, Vasileios Gkinis, Jeffrey P. Severinghaus, Feng He, Benoit S. Lecavalier, Philippe Kindler, Markus Leuenberger, Anders E. Carlson, Bo Vinther, Valérie Masson-Delmotte, James W. C. White, Zhengyu Liu, Bette Otto-Bliesner, Edward J. Brook

[Report] The coffee genome provides insight into the convergent evolution of caffeine biosynthesis

The genetic origins of coffee’s constituents reveal intriguing links to cacao and tea. Authors: France Denoeud, Lorenzo Carretero-Paulet, Alexis Dereeper, Gaëtan Droc, Romain Guyot, Marco Pietrella, Chunfang Zheng, Adriana Alberti, François Anthony, Giuseppe Aprea, Jean-Marc Aury, Pascal Bento, Maria Bernard, Stéphanie Bocs, Claudine Campa, Alberto Cenci, Marie-Christine Combes, Dominique Crouzillat, Corinne Da Silva, Loretta Daddiego, Fabien De Bellis, Stéphane Dussert, Olivier Garsmeur, Thomas Gayraud, Valentin Guignon, Katharina Jahn, Véronique Jamilloux, Thierry Joët, Karine Labadie, Tianying Lan, Julie Leclercq, Maud Lepelley, Thierry Leroy, Lei-Ting Li, Pablo Librado, Loredana Lopez, Adriana Muñoz, Benjamin Noel, Alberto Pallavicini, Gaetano Perrotta, Valérie Poncet, David Pot, Priyono, Michel Rigoreau, Mathieu Rouard, Julio Rozas, Christine Tranchant-Dubreuil, Robert VanBuren, Qiong Zhang, Alan C. Andrade, Xavier Argout, Benoît Bertrand, Alexandre de Kochko, Giorgio Graziosi, Robert J Henry, Jayarama, Ray Ming, Chifumi Nagai, Steve Rounsley, David Sankoff, Giovanni Giuliano, Victor A. Albert, Patrick Wincker, Philippe Lashermes

[Report] C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

In flies, arginine-rich proteins and RNA repeats contribute to a common genetic cause of neuronal cell death. [Also see Perspective by West and Gitler] Authors: Sarah Mizielinska, Sebastian Grönke, Teresa Niccoli, Charlotte E. Ridler, Emma L. Clayton, Anny Devoy, Thomas Moens, Frances E. Norona, Ione O. C. Woollacott, Julian Pietrzyk, Karen Cleverley, Andrew J. Nicoll, Stuart Pickering-Brown, Jacqueline Dols, Melissa Cabecinha, Oliver Hendrich, Pietro Fratta, Elizabeth M. C. Fisher, Linda Partridge, Adrian M. Isaacs

[New Products] New Products

A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.

[Editorial] Australia needs a strategy

Australians are constantly told that our economy is ‘“in transition.”’ We need to move up the global value chain, build knowledge-based industries, prepare for the Asian Century, and be the “food bowl of the world.” These are grand ambitions that we share with many other nations, in our region and beyond. The question for all of us is: How? Author: Ian Chubb

[In Depth] Supernova breaks the mold

A massive explosion in a nearby galaxy both confirms and confounds astronomers' expectations. Author: Daniel Clery

[Feature] In search of Green Arabia

Researchers are scouring the now-barren Arabian Peninsula to uncover its hidden role in ancient human migration. Author: Andrew Lawler

[Perspective] Glimpsing glass structure under pressure

Nuclear magnetic resonance spectroscopy of a glass under pressure adds to our understanding of network structure [Also see Report by Edwards et al.] Author: Randall E. Youngman

[Perspective] On the origin of Peter Rabbit

Domestication of rabbits led to changes across the genome, particularly in regions related to brain development [Also see Report by Carneiro et al.] Author: Kirk E. Lohmueller

[Perspective] One good cosmic measure

Radio-wave interferometry provides an accurate measurement of cosmic distances [Also see Report by Melis et al.] Author: Léo Girardi

[Perspective] Many modes of motility

Cells use a piston-driven mechanism, among others, to migrate [Also see Report by Petrie et al.] Authors: Douglas W. DeSimone, A. Rick Horwitz

[Perspective] Stories of Arctic colonization

Genetic data elucidate the population history of the North American Arctic [Also see Research Article by Raghavan et al.] Author: Robert W. Park

[Perspective] Rekindled HIV infection

What does the “Mississippi baby” tell us about curing HIV-1 infection? Authors: Janet D. Siliciano, Robert F. Siliciano

[Technical Comment] Comment on “The hologenomic basis of speciation: Gut bacteria cause hybrid lethality in the genus Nasonia”

Brucker and Bordenstein (Reports, 9 August 2013, p. 667) claim that adaptive codivergence of gut bacteria with hosts contributes to hybrid lethality. Yet, they provide no evidence for coadaptation of bacteria and Nasonia hosts. Their data on hybrid viability suggest that bacteria contribute to inviability only because intrinsic hybrid dysfunction increases susceptibility to free-living bacteria. Hologenomic speciation remains testable speculation without experimental support. Authors: James Angus Chandler, Michael Turelli

[Technical Response] Response to Comment on “The hologenomic basis of speciation: Gut bacteria cause hybrid lethality in the genus Nasonia”

Chandler and Turelli postulate that intrinsic hybrid dysfunction underscores hybrid lethality in Nasonia. Although it is a suitable conception for examining hybrid incompatibilities, their account of the evidence is factually inaccurate and leaves out the evolutionary process for why lethality became conditional on nuclear-microbe interactions. Hybrid incompatibilities in the context of phylosymbiosis are resolved by hologenomic principles and exemplify this emerging postmodern synthesis. Authors: Robert M. Brucker, Seth R. Bordenstein